Prepackaged Nasal Spray (generic naloxone, Narcan ®, Kloxxado ® ), developed as a result of NIDA-funded research, is an FDA-approved prefilled, needle-free device that requires no assembly and is sprayed into one nostril while the person lays on their back.These outcomes suggest that the approved prepackaged nasal spray technology is preferable over non-FDA-approved forms. Additionally, the FDA-approved naloxone devices have been shown to produce substantially higher blood levels of naloxone than the improvised nasal spray. However, this improvised intranasal device is not easy to assemble, especially when under pressure in an emergency, and requires training beforehand. Note: Some people use an improvised nasal spray emergency kit not approved by the FDA that combines injectable naloxone with an attachment designed to deliver naloxone through the nose.The FDA recently approved Zimhi TM, a single-dose, prefilled syringe that can be injected into the muscle or under the skin. Usually, it is injected with a needle into muscle, although it also may be administered into a vein or under the skin. Typically, the proper dose must be drawn up from a vial. Injectable brands of naloxone are offered by different companies listed in the FDA Orange Book under “naloxone” (look for “injectable”).You should also read the product instructions and check the expiration date. No matter what dosage form you use, it’s important to receive training on how and when to use naloxone. Naloxone comes in two FDA-approved forms: injectable and prepackaged nasal spray. Steps for responding to an opioid overdose can be found in the Substance Abuse and Mental Health Administration’s (SAMHSA) Opioid Overdose Prevention Toolkit.įirst Responders Can Safely Administer Naloxone during the COVID-19 Pandemic (HHS) What are the different naloxone delivery systems? Naloxone can be given as a nasal spray or it can be injected into the muscle, under the skin, or into the veins. Naloxone should be given to any person who shows signs of an opioid overdose or when an overdose is suspected. Examples of opioids include heroin, fentanyl, oxycodone (Ox圜ontin ®), hydrocodone (Vicodin ®), codeine, and morphine. But, naloxone has no effect on someone who does not have opioids in their system, and it is not a treatment for opioid use disorder. Naloxone can quickly restore normal breathing to a person if their breathing has slowed or stopped because of an opioid overdose. This means that it attaches to opioid receptors and reverses and blocks the effects of other opioids. Naloxone is a medicine that rapidly reverses an opioid overdose. What are some signs of an opioid overdose?
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